Glucovation

First Ever Wearable Sensor to Monitor Your Metabolism


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Glucovation's SugarSenz™ is the first body-worn sensor for glucose, granting users insight into their personal metabolic activity for the first time ever. 

This complex metabolic data is then distilled into a few user-friendly metrics that can translate to incredible health transformations and quality of life improvements.

The sensor is painlessly inserted under skin via a simple "place and go" applicator, where it detects glucose levels electrochemically via Glucovation's proprietary sensing technology. A SugarSenz™ sensor lasts 7 days and broadcasts your updated stats to your smartphone, smartwatch, or activity tracker every five minutes, giving you real-time insight into how your diet and fitness choices impact your metabolism, day and night. 

There are massive benefits for health, wellness and fitness in seeing your individual metabolic response to diet and exercise. The SugarSenz™ will be useful for everyone concerned with health and fitness, but especially those who are obese and pre-diabetic. At the bare minimum, reducing your glucose variability can lengthen your life: blood sugar variability has been linked to cardiovascular disease and increased mortality.

This might be a shocking revelation to some. But the fact is, when you eat a "bad" meal—or a meal that is high in carbohydrates—your blood sugar spikes, causing the body to respond with insulin. When you spike too high and too fast, your body will overproduce insulin, plunging your glucose levels far below a healthy level and leading to low blood sugar. And low blood sugar triggers cravings — which means you're more likely to eat unhealthy snacks and treats, starting the vicious cycle all over again. 

The SugarSenz™ is a huge innovation in not just the realms of health and fitness, but in the diabetes space as well. Glucovation's founders have decades of combined experience at Dexcom—one of only two leaders in the diabetes sensors market—designing their most advanced sensing products. Now, we've forged our own path, creating the technology to eliminate the current calibration method. Used by nearly all diabetics, pre-diabetics and anyone else monitoring their blood sugar, the "prick and track" method requires pricking your finger to draw blood every single time you want to know your levels. This is an irritating inconvenience in the lives of those individuals who necessitate it for their wellbeing, and a major barrier to entry for anyone else. With the release of SugarSenz™ technology into the health and fitness market, glucose sensing will be an attractive, viable option for a much larger audience than ever before. 

Insight into your metabolic activity can be used in a number of ways, depending on your specific needs and goals. We have developed some consumer-oriented metrics that provide a few different useful perspectives. 

The Glucose Variation Index™ is the primary metric we deliver. Excessive glucose in the blood and high glucose excursions have been linked to a number of health issues and the higher the glucose variation the worse the index and the more likely long term complications will result from poor diet and exercise. The lower the variability the better the diet and exercise programs and the better likelihood of good future health. All SugarSenz™ users will benefit from incorporating these insights into their lifestyle choices.

Glucose Rate Indicator™ is an exercise intensity indicator. The faster and deeper the drop in glucose during exercise, the higher the intensity of the exercise. This metric helps determine the intensity of metabolic demand during exercise, and will be used to prevent 'hitting the wall' or 'bonking' when doing endurance sports like cycling or running. 

SugarSenz™ users who want to lose weight will appreciate the Total Daily Glucose Index™ and Glucose Meal Index™ metrics. TDGI can be either a glucose deficit (indicating weight loss) or glucose surplus (indicating weight gain). Combining this with glucose variability metrics could give one a much more complete understanding of their individual metabolic profile. GMI calculates this for each individual meal, deriving further feedback on your diet and meal selection. It is incredibly helpful to know how your body is responding at any given time, since other variables can influence the body's response to food. It has been proven that the same meal can be eaten by the same individual at the same time of day and still you will derive two different glucose profiles, due to various physiologic factors. Therefore, being able to study patterns and the constant feedback provided by the SugarSenz™ can help you to develop a far deeper understanding of how your metabolism works. 

For too long, people have been relying on measuring their heart rate to estimate and predict how many calories they burn. But correlation of heart rate with calories has only been proven accurate at higher heart rates and higher levels of exertion — resulting in a massive over-prediction of calories burned at low to moderate heart rates. A combination of glucose (either GRI or TDGI) and heart rate could be used to enhance the correlation of caloric burn at low to moderate exercise intensity, with unprecedented precision. 

Glucovation has achieved several milestones in our efforts to develop SugarSenz™.

Completed testing of alpha prototypes

Expected completion of beta prototype testing: late Q2/early Q3 2014

Currently developing an applicator

Filed IP on core technologies

Garnered interest from Garmin, Basis, Microsoft, Samsung

Glucovation named San Diego Cool Company

Glucovation named one of San Diego's 2014 “Cool Companies"

- 30 San Diego-based businesses to be featured in front of 700 attendees, including at least 100 venture capitalists at the San Diego Venture Group June 19th Venture Summit

 

Featured in:

Glucovation: A CGM Sensor for Non-Diabetics? - Diabetes Mine

Beyond step-counting: The future of wearables - CNET

Glucovation SugarSenz Aims to Introduce Continuous Glucose Monitoring to Consumer Market (VIDEO)- Medgadget

Dexcom alums develop blood sugar-sensing wearable for health-conscious consumers - MobiHealthNews

Featured on DC Rainmaker after appearance at CES 2014

Robert Boock, PhD, CEO/CTO, previously served as the Senior Technical Director of Research and Development at Dexcom, where he was responsible for managing all long-term research including technology for their future generation sensor products. He was responsible for development of materials for Dexcom's SEVEN PLUS and invented the entire G4 Platinum sensor and led its development and commercialization. He has over 20 years of medical device industrial experience and is an expert in materials and device/tissue interface and has invented and launched successful commercial products in numerous fields. Dr. Boock received his Doctorate in Bioengineering from the University of Pennsylvania. He holds more than 44 patents and over 100 pending patents as well as having more than 25 peer reviewed journal articles. 

Jeff Suri, PhD, VP Sensor Technologies, has 13 years of experience developing glucose sensing technologies and platforms. At Dexcom Dr. Suri served as a Senior Scientist where he led the hands-on development of next generation sensor technology. He played critical roles in fundamental membrane research, process development, and manufacturing of the G4 Platinum sensor, the most recent product launched by Dexcom. Prior to Dexcom, Dr. Suri helped start GluMetrics, a company focused on developing a fluorescence-based glucose sensor for the critical care market. As Director of Chemistry and Sensor Technology he invented the core chemistry for a boronic acid based glucose sensor. Dr. Suri holds a PhD in organic chemistry from University of California, Santa Cruz. He carried out postdoctoral research at The Scripps Research Institute. He has presented at numerous conferences, has 4 issued and multiple pending patents in glucose sensing technology and over 20 publications in the fields of organic and polymer chemistry. 

Ken San Vicente, VP Electronics and Software, has 30 years of experience in hardware/software systems development and previously served as a Principal Engineer at Dexcom where he was the systems architect and project lead for their latest generation transmitter/receiver system. He led a team responsible for building the sensor interface electronics, system firmware, glucose value generating algorithm, and wireless procol definition/implementation on the transmitter and corresponding receiver side wireless implementation and user interface cell phone application. Kenneth received his Bachelor's in Mathematics and Computer Science from the University of California at Los Angeles and his Master's in Business Administration from the University of California at Irvine and has 8 issued patents on wireless Continuous Glucose Monitoring (CGM) systems. 

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