trineOMICS, Inc.

MultiOmic solutions to Predict, Prevent, Detect and Treat ASCVD


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trineOMICS: fast facts
PRECISION MEDICINE, PERSONALIZED CARE

TrineOmics’ vision of Precision Medicine, Personalized Care is to
Collaborate with Providers to 




we catch problems early;
and deliver personalized solutions

PRECISION MEDICINE, PERSONALIZED CARE

key features / Polygenic Risk Score
PRECISION MEDICINE, PERSONALIZED CARE
 

The Polygenic Risk Score (PRS for CAD ) calculates lifetime pre-dispositional risk. Available at birth, PRS is the earliest risk factor we can identify. Made possible by the UK Biobank, this tool measures risk contributions from 1.76 million variants

Used by itself, the
PRS for CAD can identify individuals who have 4 times the risk of CAD than the median

Used together with currently used cardiology risk markers,
PRS for CAD can help identify individuals with 15 times the risk of CAD than the median

key features / RNA (Transcriptomics)
PRECISION MEDICINE, PERSONALIZED CARE

Our collaborators at Georgia Tech and Emory University have published additional biomarkers that are highly predictive of cardiovascular death in the high-risk CAD population.

Analysis of 250 RNA transcripts discovered marker concentrations that correlated with High Risk (Blue) and Low Risk (Red) of mortality over a 5 year period.

The ‘Low PC1’ transcriptional score (in Blue) explained more than 5X the influences of hypertension and total cholesterol in a multivariate model

In addition, Four protein biomarkers provided independent and cumulatively highly informative discrimination of cardiovascular death

key features / MultiOmics Analytics
PRECISION MEDICINE, PERSONALIZED CARE

Our collaborators at UCSF have identified biomolecular markers that are highly correlated with the core biological processes underlying CVD – Lipids, Efflux and Inflammation

We are raising funds for a pilot study combining DNA, RNA, common clinical markers,  and the innovative markers discovered by UCSF.

This holds promise for a next generation tool set for Preventive Cardiologists

traction & accomplishments
PRECISION MEDICINE, PERSONALIZED CARE









meet the team
PRECISION MEDICINE, PERSONALIZED CARE


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