Varigen Biosciences

Synthetic biology-enabled meta/genomic drug discovery


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Leadership team with deep subject matter expertise

Key problems in drug discovery

Natural products: A billion-year head start in lead identification

Why aren’t there more (recent) natural product drugs?

Metagenomics expands access to chemical space favored by evolution

VISION
To realize the therapeutic potential of all microbial natural products

MISSION
Express and structurally modify any metabolite encoded in the microbiome

GOAL
Produce novel pre-clinical drug candidates for “must-do” targets in pharma

Two discovery approaches: (1) sequence-based and (2) function-based

How we are different –
Varigen eliminates inefficiencies in the metagenomics discovery process

How we are different –
BigDNA® BAC libraries accommodate larger inserts than fosmid libraries

Functional screening of BigDNA® Soil Library yields clones that produce antibiosis activity

Genome mining the Varigen way –
DNAtrap™ captures gene clusters from diverse sources in 5 days!

BGCXpress™: dual promoter boosts yields of end-product metabolite

Technical capability: Comparison with competitors

Clients, past and present

Varigen: Differentiated technologies for natural product drug discovery, structural modification and production

Ways of working together

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